Figure 7.

Enrichment analysis based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway identified genes with significantly differential expression. DEGs were strongly associated with environmental information processing, organismal systems, and human diseases. The expression of PON1, Bex2, Igfbp6, and Scgb1c1 was significantly increased following treatment with ASC-derived EVs in asthmatic mice. Gene ontology analysis showed that these upregulated genes were mainly involved in immune system processes and their regulation, cellular and single-organism processes, and biological regulation. These altered genes may be involved in the amelioration of allergic airway inflammation through treatment with ASC-derived EVs.