Figure EV2. Spearman's correlation between deep mutational scanning (DMS) results and variant effect predictions within and outside of areas covered by protein structures.

We assess ADRB2 (77% DMS coverage), BRCA1(b) (64% DMS coverage) and P53 (68% DMS coverage) using three predictors that incorporate some structural information (DEOGEN2, MPC and PolyPhen2_HumDiv) and predictors that do not use structures (SIFT4G and SNPs&GO). This figure shows that, while predictions tend to be much better for regions covered by known protein structures, a similar trend is observed for predictors that do and do not use structures, suggesting that the inclusion of structural information does not markedly improve the performance of VEPs.