Figure EV3. Assessment of the identification of pathogenic missense variants by deep mutational scanning (DMS) data sets and variant effect predictors (VEPs) using precision–recall curves.

Precision–recall AUCs for DMS data sets and VEP predictions distinguishing between pathogenic missense variants from ClinVar and putatively benign missense variants from gnomAD. Separate plots have been drawn for DMS assays where they do not cover the same variants to maintain class balance. The sizes of both classes are indicated on the plot. The different DMS data sets for each protein are described in Table EV11.