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. 2020 Jul 6;16(7):e9405. doi: 10.15252/msb.20199405

Figure 5. Robust pharmacological associations.

Figure 5

  1. Diagram representing how genomic and gene expression data sets are integrated to identify significant associations with drug–gene pairs that were previously found to be significantly correlated.
  2. Number of drug–gene pairs with at least one significant association with drug response, gene fitness or both, considering either genomic or gene expression profiles.
  3. Canonical examples of robust pharmacological associations. Box‐and‐whisker plots show 1.5× interquartile ranges and 5–95th percentiles, centres indicate medians.
  4. Representative example of a BIRC2/BIRC3 inhibitor, IAP_5620, showing the significant associations (FDR‐adjusted likelihood‐ratio test P‐value < 10%) with CRISPR gene fitness profiles and their location in a representation of the TNF pathway. Bar plot is defined similarly to Fig 3.