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. 2020 Jul 6;16(7):e9405. doi: 10.15252/msb.20199405

Figure EV5. Robust pharmacological associations.

Figure EV5

  • A
    Most frequent genomic alterations across the cancer cell lines.
  • B, C
    Most significant associations between (B), genomic features and (C), gene expression profiles with drug response and gene fitness.
  • D
    Number of significant drug–gene pairs across the different types of interactions. Drug–gene pairs were categorised considering the shortest path length between the drug target(s) and the associated gene. T represents the drug target and “−” represents no link was found.
  • E
    Robust pharmacological association between the expression of BCL2L1 and the significantly correlated pair of MCL1_1284 drug and MCL1 gene fitness profile.
  • F
    Similarly to (E), but instead it represents a robust pharmacological association between BAX and MDM2 and Nutlin‐3a.