Extended Data Fig. 8|.

Heatmaps of gene expression changes following LSD1 and BRD9 inhibition indicate that LSD1 and BRD9 regulate an overlapping set of genes in an antagonistic manner. a, b, RNA-seq was performed with n = 2 biologically independent replicates of MKL-1 cells treated with DMSO, GSK-LSD1 (LSD1i, 0.1 μM), dBRD9 (0.1 μM), or both GSK-LSD1 and dBRD9 for six days. a, Top 50 most differentially expressed genes between LSD1i and LSD1i + dBRD9 are shown. Differential gene expression analysis was performed using DESeq2 and p-values were adjusted by Benjamini-Hochberg. b, All differentially expressed genes (3392 genes; FDR