Table 2.

Summary of adverse events following lumbar punctures in the MADCO-PC and INTUIT studies. Percentages reflect the number of adverse events over the total numbers of LPs performed in each study. PLPH, post-lumbar puncture headache.

Adverse Events	MADCO-PC (n=553)	INTUIT (n=256)	Total (n=809)
Leptomeningeal infection	0	0	0
Subarachnoid hemorrhage	0	0	0
PLPH requiring blood patch	1	0	1
PLPH not requiring a blood patch	1	2	3
Non-PLPH headache, nausea, vagal responses	6	6	12
Lower back pain	4	2	6
Total Adverse Events (N)	12	10	22
Percentage	2.17%	3.91%	2.72%
Event Rate (95% CI)	(1.13, 3.76)	(1.89, 7.07)	(1.71, 4.09)