Table 3.
Demographic, clinical comorbidity, nutritional status, liver fibrosis stage, virological, cytokine genotyping data of the chronically hepatitis C virus-infected patients with (n = 51) and without type 2 diabetes (n = 194)
| Variables | Type 2 diabetes, n (%) | Non-type 2 diabetes, n (%) | P value |
| Demographic | |||
| Male | 27 (52.9) | 102 (52.6) | 1.0 |
| Female | 24 (47.1) | 92 (47.4) | |
| Age (yr)1 | 55.5 ± 9.6 | 50.9 ± 11.7 | 0.01 |
| Clinical comorbidity | |||
| Blood hypertension | 36 (70.6) | 62 (32.0) | < 0.001 |
| Nutritional status | |||
| Body mass index (Kg/m2)2 | 27.0 (24.1-29.7) | 25.6 (23.5-28.4) | 0.11 |
| Stage of liver disease | |||
| Chronic hepatitis C | 28 (54.9) | 123 (63.4) | 0.34 |
| Liver cirrhosis | 23 (45.1) | 71 (36.6) | |
| Virological parameters | |||
| Viral load HCV-RNA [Log10 (IU/mL)]2 | 5.98 (5.66-6.24) | 5.84 (5.30-6.40) | 0.38 |
| Genotype 1 | 40/45 (88.9) | 130/159 (81.7) | 0.37 |
| IL-6 polymorphism | |||
| IL-6-174G/G genotypes | 0.04 | ||
| G/G | 37 (72.5) | 105 (54.1) | |
| G/C | 13 (25.5) | 72 (37.1) | |
| C/C | 1 (2.0) | 17 (8.8) | |
| Total | 51 (100.0) | 194 (100.0) | |
| HWE (P value) | 0.65 | 0.47 |
1
mean ± SD.
2
Median and IQR, 25th-75th percentile. HCV: Hepatitis C virus; n: Number of subjects; IL: Interleukin; HWE: Hardy-Weinberg Equilibrium. The asymptotic Pearson’s χ2 test was used to compare categorical variables. The t test and Mann-Whitney U test were used for comparison of means and medians, respectively. P ≤ 0.05 were considered significant.