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. 2020 Apr 27;217(7):e20191736. doi: 10.1084/jem.20191736

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© 2020 Tenthorey et al.

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Figure S1. — NAIPs, not NLRP3, are required for NLRC4 signaling. (A) Macrophages were left untreated or primed for 4 h with 2 µg/ml LPS and then treated with 10 µM nigericin. LDH release was measured at 4 h after treatment. (B) Unprimed macrophages were infected with S. Typhimurium at an MOI of 5, and LDH release was measured after 4 h. (A and B) All data are representative of three independent experiments (three biological replicates per experiment). Mean ± SD; n.d., not detectable.