Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 May 5;217(7):e20191369. doi: 10.1084/jem.20191369

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Santos et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 3. — Combined totals of individual antigen-specific T cell IFN-γ ELISPOT counts correlate with PFS. (A) Summary graphs for CD8, CD4, total (CD8+CD4), and bulk (total PBMCs) IFN-γ ELISPOT counts (net count total for the three shared antigens at d43) with respect to T cell responses, as defined in Materials and methods. Test groups: CD8⁺ selected T cells responding to either autologous “iDCs” (immature DCs) transduced with a single MA-encoding AdV or (in HLA-A2⁺ patients) T2 cells pulsed with well-characterized immunodominant peptides; CD4⁺ selected T cells responding to autologous iDCs transduced with single MA Adv; and bulk (total PBMCs) T cell responses to autologous iDCs transduced with single MA AdV. ****, P ≤ 0.0001. (B) Kaplan-Meier survival analysis of OS and PFS comparing the survival benefits of positive CD8, CD4, combined CD8+CD4, and bulk responses. The log rank test was used to compare the Kaplan-Meier curves.