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. 2020 May 5;217(7):e20191369. doi: 10.1084/jem.20191369

Figure 4.

Figure 4.

Effect of previous treatment with checkpoint blockade on MA-specific T cell responses. Melanoma patients were plotted separately based on whether patients received checkpoint blockade before trial enrollment and DC vaccination. Patients in the “Previous Checkpoint Therapy” panels received α–CTLA-4 and/or α–PD-1 before DC vaccination. (A) IFN-γ ELISPOT counts for CD8 T cell responses against Tyros368–376, MAGE-A6271–279, and MART-127–35 (n = 28; 15 no blockade, 13 with blockade) were compared between patient groups across the entire time course. (B) Frequencies of dextramer-specific CD8 T cells for Tyros368–376, MAGE-A3271–279, and MART-127–35 (n = 16; 9 no blockade, 7 with blockade) were compared between patient groups across the entire time course. (A and B) Differences were characterized by linear mixed model analysis, with results listed in Table 1. Prev., previous; Tyros, tyrosinase.