Table 1. Protein profiling in circulating lymphocytes.
| Protein namea | CD name | FCb | Adjusted P valuec |
|---|---|---|---|
| Baseline PD vs. SD/PR | |||
| CTLA-4 | CD152 | 1.8 | 0.388 |
| NCAM | CD56 | 1.66 | 0.388 |
| CD45RO | CD45RO | 1.52 | 0.388 |
| d43 PD vs. SD/PR | |||
| CTLA-4 | CD152 | 1.39 | 0.786 |
| PD-1 | CD279 | 1.59 | 0.743 |
| CD45RO | CD45RO | 1.69 | 0.450 |
| BTLA | CD272 | −1.75 | 0.450 |
| CD19 | CD19 | −1.8 | 0.743 |
| HLA-DRA | HLA-DRA | −1.84 | 0.450 |
| CD40 | CD40 | −2.04 | 0.450 |
NanoString protein profiling was used to test elutriated circulating lymphocytes. n = 16 (at baseline: 1 PR, 6 SD, 9 PD), and n = 11 (at d43: 1 PR, 4 SD, 6 PD). Immune checkpoint molecules are in bold.
a
Common protein name is listed. CD, cluster of differentiation name. FC, fold change.
b
Fold change is shown, where positive expression is higher in PD (Bad) compared to SD/PR (good) patient group. Negative correlations are shaded.
c
False discovery rate adjusted P value was calculated using Benjamini Hochberg correction.