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. 2020 May 6;217(7):e20191453. doi: 10.1084/jem.20191453

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© 2020 Tay et al.

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Figure 3. — HDAC3 inhibits the cytotoxic response early during CD8 T cell priming. 5 × 10⁵ CFSE-labeled CD45.2⁺ OT-I T cells from Hdac3-KO mice or Hdac3-WT littermates were transferred into CD45.1⁺ TCR polyclonal recipients. Mice were immunized with OVA + poly(I:C) in PBS. Inguinal LNs draining the immunization site were collected for flow-cytometric analysis. (A–D) Kinetics of acquisition for markers of CD8 T cell effector function in OT-I T cells 48 h after immunization. Flow cytometry plots are representative of two independent experiments with five recipient mice per genotype of donor OT-I T cells transferred. (E–H) Kinetics for acquisition of markers of CD8 T cell effector function in OT-I T cells 96 h after immunization. Flow cytometry plots are representative of two independent experiments with five recipient mice per genotype of donor OT-I T cells transferred. Means ± SD are indicated (A–H). P values were calculated by two-way ANOVA. *, P < 0.05, **, P < 0.01, ****, P < 0.0001.