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. 2020 May 12;217(7):e20190742. doi: 10.1084/jem.20190742

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© 2020 He et al.

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Figure 7. — IL-10R is required on T cells for Blimp-1 expression and Th2 cell development. Analysis of lung tissue isolated from control (IL-10Rα^f/f CD4Cre⁻) or IL10Rα^CD4Cre (IL-10Rα^f/f CD4Cre⁺) animals i.n. immunized with HDM. (A) Percent of T cell subsets isolated from lungs (gated on live CD4⁺ TCRβ⁺ FoxP3⁻ [non-T reg] or FoxP3⁺ [T reg]). (B) Percent of Blimp-1⁺ cells (gated on live CD4⁺ TCRβ⁺ FoxP3⁻ CD44⁺). (C) Percent of eosinophils in the BAL. (D) Percent of Bcl6⁺ and IL-10⁺ T cells isolated from lungs (gated on live CD4⁺ TCRβ⁺). Data in A–D are from two experiments with 11 or 12 mice per group, mean ± SD. Mann–Whitney t test. *, P < 0.05; **, P < 0.01.