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. 2020 May 12;217(7):e20190742. doi: 10.1084/jem.20190742

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© 2020 He et al.

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Figure 9. — Blimp-1 supports Th2 development through suppression of Bcl6. Analysis of lungs isolated from control, Bcl6^CD4Cre (Bcl6^f/f CD4Cre⁺), Blimp-1^CD4Cre(Blimp-1^f/f CD4Cre⁺), or doubleKO^CD4Cre (Bcl6^f/f Blimp-1^f/f CD4Cre⁺) animals i.n. immunized with HDM. (A) PAS staining (scale bar, 100 µm). (B) Percent of eosinophils in the BAL. (C) Percent of Th1 (IFN-γ⁺ T-bet⁺), Th2 (IL-13⁺ GATA3⁺), and T reg (FoxP3⁺) cells isolated from lungs (gated on live CD4⁺TCRβ⁺ [T reg], and FoxP3⁻ [non-T reg]). (D) Total IgE in serum. (E) Flow analysis of IL-10 and FoxP3 T cells isolated from lungs of indicated mice after HDM-induced allergic asthma. Gated on live TCRβ⁺ CD4⁺. (F) Percent and geometric (Geo) MFI of IL-10⁺ cells in effector (CD4⁺TCRβ⁺FoxP3⁻) or T reg (CD4⁺TCRβ⁺FoxP3⁺) cells in lung. Data from B–F are pooled from three experiments with 7–17 total mice per group, mean ± SD. Kruskal–Wallis one-way ANOVA. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.