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. 2020 Jun 25;217(7):e20200885. doi: 10.1084/jem.20200885

Table 1. Studies that have proposed an activating ligand for ZBP1 and the timeline for their initial publication.

Study Proposed ligand for ZBP1 Pathogen
Takaoka et al., 2007 (July 8, 2007) B-DNA N/A
Kuriakose et al., 2016 (August 5, 2016) RNA virus (IAV) and RNA genome-associated proteins IAV
Thapa et al., 2016 (October 13, 2016) IAV genomic RNA IAV
Sridharan et al., 2017 (June 12, 2017) MCMV RNA transcripts MCMV
Kesavardhana et al., 2017 (June 20, 2017) IAV RNA genome (RNA associated with nucleoprotein) IAV
Maelfait et al., 2017 (July 17, 2017) MCMV RNA, endogenous RNA, and Z-RNAs MCMV
Zhang et al., 2020 (March 19, 2020) IAV viral Z-RNAs IAV
Jiao et al., 2020 (March 25, 2020) Endogenous Z-nucleic acids, ERV RNAs N/A
Wang et al., 2020 (March 25, 2020) Endogenous Z-nucleic acids, ERV RNAs N/A
Devos et al., 2020 (April 21, 2020) Endogenous Z-nucleic acids N/A
Kesavardhana et al., 2020 (April 29, 2020) IAV Z-RNAs and endogenous Z-nucleic acids IAV

N/A, not applicable.