Table 1:
Characteristics of final analysis set of 913 DM1 patients and 12,318 DM1-free controls by type 2 diabetes status.
| DM1 Cohort (n=913) | DM1-free Cohort (n=12,318) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Characteristic | Type II Diabetes (n=75) | No diabetes (n=838) | Type II Diabetes (n=412) | No diabetes (n=11,906) | |||||
| Age at DM1 diagnosis (years) | |||||||||
| median (range) | 43.6 | (0–64) | 31.0 | (0–91) | - | - | - | - | |
| Age at start of follow-up (years) | |||||||||
| median (range) | 50.4 | (23–71) | 36.5 | (18–96) | 52.9 | (23–87) | 34.6 | (18–97) | |
| Gender, n (%) | |||||||||
| Male | 37 | (49.3%) | 411 | (49.1%) | 251 | (60.9%) | 5,800 | (48.7%) | |
| Female | 38 | (50.7%) | 427 | (50.9%) | 161 | (39.1%) | 6,106 | (51.3%) | |
| Metformin use | |||||||||
| Yes, n (%) | 56 | (74.7%) | - | - | 276 | (67.0%) | - | - | |
| Time from diabetes to 1st prescription in years, median (range) | 1.5 | (0–23.5) | - | - | 1.5 | (0–16.5) | - | - | |
| Cancer | |||||||||
| Yes, n (%) | 7 | (9.3%) | 34 | (4.1%) | 70 | (17.0%) | 631 | (5.3%) | |
| Age at diagnosis, median (range) | 57.4 | (44–62) | 56.4 | (34–96) | 65.2 | (48–87) | 60.7 | (24–97) | |
| BMI (kg/m2) | |||||||||
| <25 | 9 | (12.0%) | 279 | (33.3%) | 44 | (10.7%) | 3,179 | (26.7%) | |
| 25–29.9 | 16 | (21.3%) | 99 | (11.8%) | 79 | (19.2%) | 1,721 | (14.5%) | |
| 30+ | 28 | (37.3%) | 66 | (7.9%) | 161 | (39.1%) | 922 | (7.7%) | |
| Missing | 22 | (29.3%) | 394 | (47.0%) | 128 | (31.1%) | 6,084 | (51.1%) | |
| Mean (SD) | 31.0 | (6.5) | 24.4 | (6.0) | 31.5 | (7.6%) | 25.4 | (5.2) | |
| Smoking, n (%) | |||||||||
| Never | 22 | (29.3%) | 218 | (26.0%) | 78 | (18.9%) | 2,459 | (20.7%) | |
| Former | 25 | (33.3%) | 158 | (18.9%) | 116 | (28.2%) | 1,997 | (16.8%) | |
| Current | 8 | (10.7%) | 149 | (17.8%) | 88 | (21.4%) | 2,517 | (21.1%) | |
| Missing | 20 | (26.7%) | 313 | (37.4%) | 130 | (31.6%) | 4,933 | (41.4%) | |
| Alcohol Consumption, n (%) | |||||||||
| Never | 13 | (17.3%) | 84 | (10.0%) | 46 | (11.2%) | 982 | (8.3%) | |
| Ever | 30 | (40.0%) | 312 | (37.2%) | 180 | (43.7%) | 4,468 | (37.5%) | |
| Missing | 32 | (42.7%) | 442 | (52.7%) | 186 | (45.1%) | 6,456 | (54.2%) | |
| Death during follow-up | |||||||||
| Yes, n (%) | 39 | (52.0%) | 228 | (27.2%) | 177 | (43.0%) | 1,118 | (9.4%) | |
| Age at death, median (range) | 59.9 | (38–73) | 56.1 | (23–97) | 68.1 | (41–93) | 63.0 | (20–104) | |
| Practice-level Index of Multiple Deprivations quintiles | |||||||||
| 1 (most affluent) | 7 | (9.3%) | 121 | (14.4%) | 44 | (10.7%) | 1,646 | (13.8%) | |
| 2 | 17 | (22.7%) | 145 | (17.3%) | 52 | (12.6%) | 2,051 | (17.2%) | |
| 3 | 14 | (18.7%) | 151 | (18.0%) | 88 | (21.4%) | 2,198 | (18.5%) | |
| 4 | 10 | (13.3%) | 180 | (21.5%) | 76 | (18.4%) | 2,545 | (21.4%) | |
| 5 (most deprived) | 27 | (36.0%) | 241 | (28.8%) | 152 | (36.9%) | 3,466 | (29.1%) | |
| Healthcare visits during follow-up, mean (SD) | 15.3 | (11.9) | 9.6 | (9.3) | 12.2 | (13.7) | 3.9 | (6.1) | |
| Follow-up years, total (median) | 681.9 | (7.6) | 8,024.2 | (8.0) | 4,375.2 | (9.3) | 113,051.4 | (8.1) | |