Table 1. Effect of Lmna shRNA on cardiac function in mice.

Effect of Lmna shRNA-1 and Lmna shRNA-2 versus Ctrl shRNA on mice at a dose of 2.0E+13 vg/kg assessed at 5.5 weeks. P values represent comparisons to mice transduced with control shRNA at respective age. LVDD, left ventricular diastolic dimension; LVWT, LV wall thickness; EF, ejection fraction; FS, fractional shortening.

shRNA	Age (weeks)	n	LVDD (mm)	P	LVWT (mm)	P	EF (%)	P	FS (%)	P
Ctrl shRNA	5.5	6	3.81 ± 0.10		0.68 ± 0.10		57.80 ± 4.81		29.97 ± 3.20
Lmna shRNA-1		6	4.25 ± 0.11	2E-06	0.45 ± 0.08	2E-05	12.13 ± 3.16	4E-11	5.33 ± 1.79	8E-11
Lmna shRNA-2		5	4.30 ± 0.32	5E-04	0.43 ± 0.12	4E-03	11.66 ± 10.66	1E-05	5.42 ± 5.01	1E-05