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. Author manuscript; available in PMC: 2020 Jul 6.
Published in final edited form as: Circ Res. 2019 Sep 9;125(9):834–846. doi: 10.1161/CIRCRESAHA.119.314794

Table 2. Effect of Yy1 on Lmna DCM in mice.

Effect of Yy1 or EGFP at a dose of 0.5E+13 vg/kg on Lmna DCM mice assessed at 5.5 weeks. P values represent comparisons to Lmna DCM mice treated with EGFP. LVDD, left ventricular diastolic dimension; LVWT, LV wall thickness; EF, ejection fraction; FS, fractional shortening.

Lmna DCM Treatment Age (weeks) n LVDD (mm) P LVWT (mm) P EF (%) P FS (%) P
EGFP 5.5 5 4.23 ± 0.10 0.40 ± 0.07 14.98 ± 4.39 6.64 ± 2.03
Yy1 6 3.97 ± 0.18 0.02 0.51 ± 0.06 0.03 27.40 ± 2.55 0.0002 12.54 ± 1.27 0.0002