. Author manuscript; available in PMC: 2020 Jul 6.

Published in final edited form as: J Inherit Metab Dis. 2019 Jul 10;42(5):831–838. doi: 10.1002/jimd.12140

Table 1.

Binding affinities for CBS alleles.

CBS allele	K_m-ser (CI)	K_m-Hcy (CI)	K_act-adoMet (CI)
Wt hCBS	0.9 mM (0.6–1.2)	3.5 mM (2.7–4.2)	33 μM (21–46)
p.R336C	5.1 mM (3.6–6.7)	1.4 mM (0.9–1.9)	15 μM (10–19)
p.R336C+bortez	4.5 mM (2.9–6.0)	2.4 mM (1.0–3.8)	13 μM (7.7–18)

CI=95% confidence interval