Table 2.

Results of MANCOVA of OXTR DNA methylation between patients with OCD and healthy controls for men and women

		Men					Women
		OCDa (n = 112)	HCa (n = 56)				OCDa (n = 39)	HCa (n = 52)
				F	pb	ηp2c			F	pb	ηp2c
		Statistics: Wilks λ = 0.822, F(4, 161) = 8.693, p < 0.001					Statistics: Wilks λ = 0.736, F(4, 84) = 7.525, p < 0.001
OXTR1 (exon2)	CpG1 (-959)	40.94 ± 5.17	45.67 ± 4.88	20.012	< 0.001	0.109†	42.94 ± 5.13	47.70 ± 3.89	21.784	< 0.001	0.200‡
	CpG2 (-934)	46.33 ± 5.21	50.44 ± 4.52	22.873	< 0.001	0.122†	49.11 ± 5.75	52.54 ± 3.14	10.631	0.002	0.109†
	CpG3 (-924)	58.08 ± 5.25	59.62 ± 3.82	1.835	0.177	0.011	60.36 ± 5.86	60.74 ± 3.75	0.032	0.858	< 0.001
OXTR2 (exon3)	Mean value of CpG1-8	13.81 ± 5.46	13.34 ± 5.66	0.233	0.630	0.001	14.80 ± 4.49	14.14 ± 4.57	0.020	0.888	< 0.001

MANCOVA demonstrated significant between-group differences after controlling for age and education

MANCOVA multivariate analysis of covariance, OCD obsessive-compulsive disorder, HC healthy control

^aMean ± standard deviation of raw data

^bStatistical significance was set at p < 0.0125 after Bonferroni correction for the 4 CpG sites

^cEffect size was calculated using partial eta squared and interpreted according to the rule of Miles and Shevlin (2001)

^†Medium effect (> 0.06)

^‡Large effect (> 0.14)