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. 2020 May 21;44(2):685–697. doi: 10.3892/or.2020.7620

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — UBR5 increases M2E and M4E cell proliferation. The Cell Counting Kit-8 assay was employed to evaluate the role of UBR5 in the proliferation of M2E and M4E cells. (A and B) Silencing UBR5 significantly decreased cell proliferation, whereas (C and D) overexpression of UBR5 significantly increased cell proliferation compared with the control group. Cell cycle analysis revealed that the percentage of S phase cells was comparable among (E) untreated, (F) vector and (G) UBR5-overexpressing cells. Compared with the (H) control group, the percentage of S phase cells was significantly decreased in the (I) UBR5 si-RNA-1 and (J) UBR5 si-RNA-2 groups (P<0.05). UBR5, ubiquitin protein ligase E3 component n-recognin 5; *P<0.05; **P<0.01.

Figure 3. — UBR5 increases M2E and M4E cell proliferation. The Cell Counting Kit-8 assay was employed to evaluate the role of UBR5 in the proliferation of M2E and M4E cells. (A and B) Silencing UBR5 significantly decreased cell proliferation, whereas (C and D) overexpression of UBR5 significantly increased cell proliferation compared with the control group. Cell cycle analysis revealed that the percentage of S phase cells was comparable among (E) untreated, (F) vector and (G) UBR5-overexpressing cells. Compared with the (H) control group, the percentage of S phase cells was significantly decreased in the (I) UBR5 si-RNA-1 and (J) UBR5 si-RNA-2 groups (P<0.05). UBR5, ubiquitin protein ligase E3 component n-recognin 5; *P<0.05; **P<0.01.