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Screening space for the threshold optimization for each variant caller
| Strelka2 | Shimmer |
| Somatic EVS from 5 to 20 (steps of 0.25) | Q-value from 0.0005 to 0.05 (steps of 0.0005) |
| Mutect2 | VarScan2 |
| TLOD from 0 to 200 (steps of 1) | Somatic p-value from 0.00005 to 0.01 (steps of 0.00005) |
