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. 2020 Jun 12;44(2):599–610. doi: 10.3892/or.2020.7645

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — Depletion of OSER1-AS1 suppresses the growth of NSCLC xenograft tumors in vivo. (A) Detection of OSER1-AS1 expression in sh-OSER1-AS1 or sh-NC-stably transected H522 cells by RT-qPCR. **P<0.01, compared with the sh-NC group. (B) Images of tumor xenografts derived from sh-OSER1-AS1 or sh-NC-stably transected H522 cells. (C) Plots of tumor xenograft growth according to tumor volume. **P<0.01. (D) The weights of tumor xenografts from the sh-OSER1-AS1 and sh-NC groups. **P<0.01, compared with the sh-NC group. (E and F) Detection of OSER1-AS1 and miR-433-3p expression in tumor xenografts by RT-qPCR. **P<0.01, compared with the sh-NC group. (G) Isolation of total protein from tumor xenografts in the sh-OSER1-AS1 and sh-NC groups and measurement of Smad2 protein expression by western blotting. **P<0.01, compared with the sh-NC group. OSER1-AS1, RNA OSER1 antisense RNA 1; Smad2, mothers against decapentaplegic homolog 2; NSCLC, non-small cell lung cancer; RT-qPCR, reverse transcription-quantitative polymerase chain reaction; miR, microRNA.