Table 1.
Univariate | Multivariate | |||
---|---|---|---|---|
HR | p-value | HR | p-value | |
METABRIC | ||||
All cases (N = 1904) | ||||
Hypoxia-score | 1.30 (1.10-1.50) | <0.001*** | 1.43 (1.21-1.68) | <0.001*** |
UCP1 | 0.94 (0.84-1.10) | 0.27 | 0.96 (0.86-1.08) | 0.515 |
FABP7 | 0.99 (0.94-1.00) | 0.504 | 0.95 (0.90-0.99) | 0.02* |
ER+ (N = 1445) | ||||
Hypoxia-score | 1.40 (1.20-1.80) | <0.001*** | 1.47 (1.18-1.80) | <0.001*** |
UCP1 | 0.99 (0.88-1.10) | 0.908 | 1.01 (0.90-1.10) | 0.875 |
FABP7 | 0.97 (0.89-1.10) | 0.558 | 0.94 (0.85-1.00) | 0.214 |
ER- (N = 429) | ||||
Hypoxia-score | 1.20 (0.88-1.60) | 0.246 | 1.24 (0.89-1.70) | 0.201 |
UCP1 | 0.62 (0.28-1.40) | 0.241 | 0.64 (0.29-1.40) | 0.278 |
FABP7 | 0.95 (0.90-1.00) | 0.114 | 0.94 (0.88-1.00) | 0.053 |
TCGA | ||||
All cases (N = 960) | ||||
hypoxia-score | 1.50 (1.00-2.10) | 0.028* | 2.19 (1.46-3.28) | <0.001*** |
UCP1 | 1.00 (0.92-1.10) | 0.763 | 1.04 (0.95-1.14) | 0.403 |
FABP7 | 0.92 (0.87-0.97) | 0.003** | 0.89 (0.84-0.94) | <0.001*** |
ER+ (N = 708) | ||||
hypoxia-score | 1.40 (0.80-2.40) | 0.246 | 1.50 (0.80-2.64) | 0.216 |
UCP1 | 1.00 (0.94-1.20) | 0.403 | 1.10 (0.96-1.16) | 0.244 |
FABP7 | 0.80 (0.71-0.89) | <0.001*** | 0.80 (0.72-0.89) | <0.001*** |
ER- (N = 208) | ||||
hypoxia-score | 1.20 (0.57-2.6) | 0.601 | 1.59 (0.71-3.50) | 0.255 |
UCP1 | 1.00 (0.58-1.80) | 0.944 | 1.08 (0.60-1.90) | 0.799 |
FABP7 | 0.93 (0.86-1.00) | 0.092 | 0.92 (0.84-1.00) | 0.053 |
*p < 0.05, **p < 0.01, and ***p < 0.001