Table 1.

Prognostic impact of hypoxia score, UCP1, and FABP7

	Univariate		Multivariate
	HR	p-value	HR	p-value
METABRIC
All cases (N = 1904)
Hypoxia-score	1.30 (1.10-1.50)	<0.001***	1.43 (1.21-1.68)	<0.001***
UCP1	0.94 (0.84-1.10)	0.27	0.96 (0.86-1.08)	0.515
FABP7	0.99 (0.94-1.00)	0.504	0.95 (0.90-0.99)	0.02*
ER+ (N = 1445)
Hypoxia-score	1.40 (1.20-1.80)	<0.001***	1.47 (1.18-1.80)	<0.001***
UCP1	0.99 (0.88-1.10)	0.908	1.01 (0.90-1.10)	0.875
FABP7	0.97 (0.89-1.10)	0.558	0.94 (0.85-1.00)	0.214
ER- (N = 429)
Hypoxia-score	1.20 (0.88-1.60)	0.246	1.24 (0.89-1.70)	0.201
UCP1	0.62 (0.28-1.40)	0.241	0.64 (0.29-1.40)	0.278
FABP7	0.95 (0.90-1.00)	0.114	0.94 (0.88-1.00)	0.053
TCGA
All cases (N = 960)
hypoxia-score	1.50 (1.00-2.10)	0.028*	2.19 (1.46-3.28)	<0.001***
UCP1	1.00 (0.92-1.10)	0.763	1.04 (0.95-1.14)	0.403
FABP7	0.92 (0.87-0.97)	0.003**	0.89 (0.84-0.94)	<0.001***
ER+ (N = 708)
hypoxia-score	1.40 (0.80-2.40)	0.246	1.50 (0.80-2.64)	0.216
UCP1	1.00 (0.94-1.20)	0.403	1.10 (0.96-1.16)	0.244
FABP7	0.80 (0.71-0.89)	<0.001***	0.80 (0.72-0.89)	<0.001***
ER- (N = 208)
hypoxia-score	1.20 (0.57-2.6)	0.601	1.59 (0.71-3.50)	0.255
UCP1	1.00 (0.58-1.80)	0.944	1.08 (0.60-1.90)	0.799
FABP7	0.93 (0.86-1.00)	0.092	0.92 (0.84-1.00)	0.053

*p < 0.05, **p < 0.01, and ***p < 0.001