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. Author manuscript; available in PMC: 2020 Jul 6.
Published in final edited form as: Psychopharmacology (Berl). 2015 Nov 10;233(4):661–672. doi: 10.1007/s00213-015-4134-4

Fig. 7.

Fig. 7

Naltrexone antagonized AAV-MOR-mediated reduction in DOPAC/DA turnover in NAc of Meth-sensitized mice. AAV-GFP or AAV-MOR was injected to the NAc. Animals were treated with Meth + vehicle or Meth + naltrexone (days 1 to 5 and day 15) starting from 2 weeks after AAV-MOR or AAV-GFP injection. NAc tissue was harvested at 30 min after the last injection. a Administration of AAV-MOR or naltrexone did not alter DA level in NAc (p>0.5). b AAV-MOR significantly reduced Meth-mediated DOPAC/DA turnover in NAc (p<0.05). This reaction was antagonized by naltrexone