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. 2020 Jun 10;44(2):711–721. doi: 10.3892/or.2020.7641

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — High expression of HPSE in PC tissues and cell lines and association with survival. (A) mRNA level of HPSE in PC and adjacent normal tissues. (B) Immunohistochemical staining (magnification, ×4 and ×20) for HPSE in PC (left panel) and adjacent normal tissue (right panel). (C) Kaplan-Meier analysis of overall and disease-free survival of patients with PC according to intra-tumoral HPSE expression. (D and E) mRNA and protein levels of HPSE in normal pancreatic ductal epithelial cells (HPDE6-C7) and four PC cells (Capan-2, PANC-1, AsPC-1 and BxPC-3). Data are presented as mean ± standard deviation. GAPDH served as an internal reference. All experiments were performed three times. **P<0.01, ***P<0.001, compared with adjacent tissue or HPDE6-C7 cells, respectively. HPSE, heparanase; PC, pancreatic cancer.