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The effect of HPSE on PC progression is mediated by activating the Wnt/β-catenin signaling pathway. Representative western blots and summarized data showing the expression levels of β-catenin protein and total and phosphorylated GSK3β protein in (A) PANC-1 and (B) BxPC-3 cells. **P<0.01 vs. sh-NC group. HPSE, heparanase; PC, pancreatic cancer; GSK, glycogen synthase kinase.
