Table II.
Univariate and multivariate analysis of the correlation between clinicopathological parameters and overall survival of patients with pancreatic cancer.
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Variables | HR | 95% CI | P-value | HR | 95% CI | P-value |
| Sex | 0.868 | 0.525–1.432 | 0.579 | |||
| Male | ||||||
| Female | ||||||
| Age (years) | 0.768 | 0.468–1.260 | 0.296 | |||
| ≤60 | ||||||
| >60 | ||||||
| Size (cm) | 1.149 | 0.633–2.088 | 0.648 | |||
| ≤4 | ||||||
| >4 | ||||||
| Tumor location | 1.221 | 0.724–2.059 | 0.455 | |||
| Head and neck | ||||||
| Body and tail | ||||||
| Vascular invasion | 1.812 | 1.109–2.962 | 0.018a | |||
| Negative | ||||||
| Positive | ||||||
| Differentiation | 2.397 | 1.455–3.947 | 0.001a | 1.919 | 1.220–3.916 | 0.014a |
| High/moderate | ||||||
| Poor and undifferentiated | ||||||
| TNM stage | 1.671 | 1.027–2.721 | 0.039a | |||
| I–II | ||||||
| III–IV | ||||||
| HPSE expression | 2.682 | 1.536–4.684 | 0.001a | 2.186 | 1.140–3.229 | 0.009a |
| Low | ||||||
| High | ||||||
a
Statistically significant. HR, hazard ratio; CI, confidence interval; HPSE, heparanase.