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. Author manuscript; available in PMC: 2020 Jul 6.
Published in final edited form as: Cell Rep. 2018 Nov 13;25(7):1829–1840.e6. doi: 10.1016/j.celrep.2018.10.055

Figure 1. Characterizing the Secretion of ER Resident Proteins with ERSs.

Figure 1.

(A) Secretion of GLuc fusion proteins from transiently transfected SH-SY5Y cells under basal conditions (blue) and after 200 nM Tg for 24 hr (pink) (n = 9). Overlap of the two groups is purple. Secretion index refers to the ratio of extracellular to intracellular GLuc.

(B) Sequence logo produced by WebLogo 3.4 forproteins designated as ERS (+).

(C and D) Fold change in secretion of GLuc fusion protein from transiently transfected SH-SY5Y with (blue) or without (pink) (C) 500 nM brefeldin A (BFA) or (D) 50 μM dantrolene prior to an 8 hr exposure to 200 nM Tg (n = 6 for dantrolene, n = 12 for Tg).

See also Figures S1 and S2.