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. 2020 May 27;44(2):533–542. doi: 10.3892/or.2020.7624

Figure 1.

Figure 1.

PER2 expression is downregulated in GSCs. (A) Protein expression levels of NESTIN, CD133 and SOX2 increased in glioma sphere-forming cells line U251s and U87s. (B) Representative images of primary GSCs. (C) Relative mRNA expression of core circadian genes in normal human astrocyte cell, GSCs and matched non-GSCs glioma cell lines. (D) PER2 protein expression in those cell lines. One-way ANOVA with Tukey's post hoc test was used for statistical analysis of the results of B. *P<0.05, **P<0.01 vs. the control. PER2, period 2; GSCs, glioma stem cells.