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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: J Thromb Haemost. 2020 May 28;18(7):1535–1547. doi: 10.1111/jth.14874

Figure 1. O-glycan Core 1 and N-linked glycan structures.

Figure 1.

Addition of N-acetylgalactosamine onto Serine/Threonine (Ser/Thr) residues initiates Core 1 O-glycan synthesis (Tn-antigen). Addition of N-acetylgalactosamine by the glycosyltransferase C1GalT1 and its chaperone COMSC onto Serine/Threonine (Ser/Thr) residues the T or TF antigen. The Core 1 (seldom Core 2) sialyltransferase ST3Gal1 adds sialic acid to form Sialyl-T structure. Most cells express Sialyl-T, i.e T or TF-antigen structures are cryptic. Exposure of Tn-antigen causes the rare Tn-antigen syndrome. A common N-linked glycan structure is also shown.