Table 3:

Glycosylation and immune related disorders.

Human Syndrome	Pathophysiology and symptoms
Paroxysmal Cold Hemoglobinuria (PCH):	Autoimmune, IgG target blood group P antigen; Antibody-mediated intravascular hemolysis, anemia; red blood cells cleared by macrophages in spleen
Cold Agglutinin Disease (CAD):	Autoimmune, IgM antibodies target blood group I or i carbohydrate epitopes; bind preferentially low temperatures, antibody-mediated hemolysis and thrombocytopenia; red blood cells and platelet cleared by macrophages in spleen
Hemolytic Uremic Syndrome (HUS)	Often accompanied by infections (E.coli strains and S. pneumoniae); hemolysis, thrombocytopenia
Immune Thrombocytopenia (ITP)	Anti-GPIbα antibody induce sialidase secretion and desialylation of platelets, platelet clearance via AMR