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Plasminogen activator protease (Pla) is essential to promote early bacterial growth in the lungs. Bacterial burden in the lungs of C57BL/6 mice infected intranasally with 104 colony-forming units (CFUs) of wild-type Yersnia pestis CO92 or CO92 lacking pla (CO92 Δpla) at 6, 12, and 24 hours after infection. Experiments were performed 3 times; error bars represent standard deviations (n = 5). *P < .05; †P < .001 (Welch t test).
