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[Preprint]. 2020 Jun 1:rs.3.rs-32949. [Version 1] doi: 10.21203/rs.3.rs-32949/v1

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Figure 1. — Model overview. (a) Schematic of the 6-compartment model used to simulate distributed perfusion in aerated and injured compartments at different height levels. Deoxygenated mixed venous blood (blue) passes through aerated (black) or injured (grey) compartments, and returns to the oxygenated mixed arterial blood (red). Vascular resistance in each compartment was determined by height level as well as the degree of oxygenation or injury. Hypoxic pulmonary vasoconstriction (HPV) could be either (b) “normal” with reduced perfusion to regions of low end-capillary oxygen content, (d) “impaired” with no response, or (d) “reversed” with increased perfusion to injured regions.