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[Preprint]. 2020 Jun 1:rs.3.rs-32949. [Version 1] doi: 10.21203/rs.3.rs-32949/v1

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Figure 2. — Effects of alterations to hypoxic pulmonary vasoconstriction (HPV). Severity of pulmonary shunt with respect to fractional injury extent (F_inj), type of HPV modification (color), injury location within one height level (light to dark). Rows correspond to the ratio of arterial oxygen tension to inspired oxygen fraction (P_aO₂:F_iO₂), shunt fraction (F_shu), and ratio of shunt fraction to injured fraction (F_shu:F_inj). Columns correspond to varying degrees of impaired oxygen equilibration between capillary blood and alveolar gas in the injured region. Baseline perfusion gradient was 30%, and reversed HPV was modeled with 72% reduction of vascular resistance in injured regions. Short-dashed line in the top row indicates P_aO₂:F_iO₂ = 300 mmHg %⁻¹, a threshold for ARDS. Dotted and long-dashed lines in the bottom row indicate F_shu:F_inj ratios of 3.0 and 1.3, respectively, the values reported by Gattinoni et al. for COVID-19 and ARDS patients, respectively ⁸.