TABLE 1.
Functional characteristics of Nav1.2 channel
| Peak amplitude of Na+ current | Voltage dependence of activation | Voltage dependence of fast inactivation | Recovery from fast inactivation | ||||
|---|---|---|---|---|---|---|---|
| pA/pF | V0.5, mV | k, mV | V0.5, mV | k, mV | τ1, ms | τ2, ms | |
| WT | −607.14 ± 135.84 | −21.76 ± 1.46 | 7.40 ± 0.87 | −58.57 ± 1.40 | 4.85 ± 0.30 | 1.25 ± 0.11 | 39.07 ± 6.62 |
| E999K | −513.57 ± 101.72 | −28.56 ± 1.25** | 8.03 ± 0.52 | −59.86 ± 1.62 | 5.22 ± 0.49 | 1.03 ± 0.10* | 41.03 ± 6.02 |
| N1339D | −676.55 ± 102.04 | −26.43 ± 1.16** | 7.10 ± 0.56 | −60.30 ± 0.97 | 4.86 ± 0.59 | 0.95 ± 0.17** | 37.52 ± 7.36 |
| I1571T | −572.07 ± 104.75 | −27.57 ± 1.82** | 6.70 ± 0.72 | −59.60 ± 1.30 | 4.93 ± 0.47 | 0.61 ± 0.15** | 25.02 ± 6.14** |
| A1773T | −287.91 ± 49.32** | −29.23 ± 2.04** | 6.05 ± 0.75* | −68.76 ± 2.01** | 5.4 ± 0.74 | 1.60 ± 0.28** | 46.32 ± 5.40 |
V0.5 is voltage of half‐maximal (in‐) activation; k is slope factor; τ is time constant. Data are presented as means ± SEM, n = 12–15. *p < .05 and **p < .01 versus WT were determined by a Dunnett's post hoc test after a one way ANOVA.