Table 2.

Genes that when knocked‐out cause anorexia in mice. (www.informatics.jax.org/)

Human gene	Gene function	Knocked‐out mouse gene	Mouse features	Reference or MGI ID
PMCH	Melanin‐concentrating hormone neuropeptide	Pmch	Decrease of food intake, body weight, body adiposity	Shimada et al. (1998)
CHRM3	Regulator of glucose homeostasis by modulating insulin secretion	Chrm3	Decrease of body weight and fat mass, hypophagia	Yilmaz et al. (2015)
CNR1	Orexigenic, regulation of energy expenditure	Cnr1	Reduction of food intake and body weight	Yilmaz et al. (2015)
OPRD1	Receptor for endogenous opioids	Oprd1	Resistance to weight gain, increased thermogenesis, leanness	Czyzyk et al. (2012)
NPY2R NPY4R	Orexigenic	Npy2r Npy4r	Reduction of adipose mass, increase of lean mass	108418 105374
HCRT	Regulation of food intake and sleep‐wakefulness	Hcrt	Decreased food and water intake	1,202,306
HTR4 HTR1B HTR1A	Serotonin receptors	Htr4 Htr1B	Voluntary food restriction following stress; reduction of novelty‐induced exploratory activity	Jean et al. (2012)
DRD1 DRD2	Activation of pathways mediated by G protein‐coupled receptors	Drd1 Drd2	Hypophagia, locomotor deficiency	99578 94924
DAGLA DAGLB	Biosynthesis of 2‐arachidonoylglycerol	Dagla Daglb	Hypophagia, decreased body weight, leanness	2677061 2442032
NAPEPLD	Biosynthesis of anandamide	Napepld	Hypophagia, decreased body weight, leanness	2140885
CCK	Regulation of pancreatic digestive enzymes	Cck	Impaired fat digestion and absorption	88297
GLP1R	Stimulation of glucose‐induced insulin secretion	Glp1r	Reduction of feeding behavior	99571
CRH	Release of hormones involved in the stress response	Crh	Inhibition of food intake	88496
CYFIP1	FMR1‐mediated translation repression in the brain	Cyfip1	Disordered eating	Babbs et al. (2019)