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(a) Sanger sequencing analysis of the proband and his sibling and parents. Variant CHRNA4 c.1007G>A was detected in the proband and his younger brother and mother. (b) Pedigree chart of the family. (c) Schematic structure of CHRNA4 protein by searching the SMART database (http://smart.embl‐heidelberg.de/). The location of variant CHRNA4 c.1007G>A is indicated by a red arrow
