Table 3.

Summary of the validated variables from the external ExWAS on HDP during 2010–2013 in Florida, USA (n=819,399).

Exposure		Transformation	Discovery setb					Replication setb
Variablea	Category		Phase 1		Phase 2	Phase 3		Phase 1		Phase 2	Phase 3
			OR (95% CI)c	p-value	Coefficient	OR (95% CI)c	p-value	OR (95% CI)c	p-value	Coefficient	OR (95% CI)c	p-value
2,2,4-trimethylpentane (T12)	Air toxicant	Box Cox (λ=0.24)	0.94 (0.92, 0.95)	2.78×10−16	0.08	1.15 (1.08, 1.23)	4.91×10−5	0.94 (0.93, 0.96)	5.51×10−14	0.12	1.20 (1.13, 1.27)	2.31×10−9
Omega at 125mb pressure level (T12)	Meteorology	Square root	1.06 (1.04,1.07)	4.33×10−11	0.03	1.13 (1.04, 1.23)	2.93×10−3	1.04 (1.03, 1.06)	1.53×10−7	0.05	1.10 (1.01, 1.20)	2.91×10−2
Acrolein (T12)	Air toxicant	log10(x+0.001)	1.07 (1.05, 1.08)	2.11×10−17	0.08	1.09 (1.05, 1.13)	1.25×10−6	1.07 (1.05, 1.08)	1.51×10−18	0.06	1.06 (1.02, 1.10)	2.09×10−3
Burglary rate (T12)	Crime and safety	Exponential	1.10 (1.09, 1.12)	1.51×10−42	0.06	1.07 (1.05, 1.09)	5.78×10−9	1.10 (1.08, 1.11)	3.94×10−41	0.04	1.04 (1.02, 1.07)	2.11×10−4
1,1,1-trichloroethane (T12)	Air toxicant	Box Cox (λ=0.12)	0.95 (0.93, 0.97)	5.36×10−07	0.02	1.06 (1.01, 1.11)	1.39×10−2	0.95 (0.93, 0.97)	6.25×10−7	0.02	1.06 (1.01, 1.11)	2.25×10−2
Proportion of individuals living in a place among workers 16 years and over (T12)	Sociodemographic status and housing	Square root	0.96 (0.95, 0.98)	3.40×10−07	0.03	1.05 (1.01, 1.10)	1.68×10−2	0.97 (0.95, 0.98)	4.18×10−6	0.04	1.06 (1.03, 1.09)	3.55×10−5
Maleic anhydride (T12)	Air toxicant	log10(x+0.001)	1.08 (1.07, 1.09)	2.09×10−48	0.03	1.04 (1.01, 1.06)	2.66×10−3	1.07 (1.06, 1.08)	7.13×10−40	0.02	1.02 (1.01, 1.04)	4.67×10−2
Forcible sex offenses rate (T12)	Crime and safety	Exponential	1.12 (1.10, 1.13)	1.49×10−60	0.03	1.03 (1.01, 1.06)	4.01×10−2	1.11 (1.10, 1.13)	1.94×10−53	0.06	1.06 (1.03, 1.09)	5.47×10−5
Propylene oxide (T12)	Air toxicant	log10(x+0.001)	0.95 (0.94, 0.97)	3.09×10−09	0.02	1.02 (1.01, 1.04)	3.11×10−2	0.96 (0.95, 0.98)	5.87×10−6	0.02	1.03 (1.01, 1.05)	1.18×10−2
Proportion of individuals who speak English very well among those aged 18–64 years who speak Spanish (T12)	Sociodemographic status and housing	No transformation	0.97 (0.95, 0.98)	5.62×10−06	−0.02	0.98 (0.96, 0.99)	7.19×10−3	0.97 (0.95, 0.98)	9.57×10−7	−0.01	0.98 (0.96, 0.99)	4.85×10−2
Omega at 100mb pressure level (T2)	Meteorology	log10(x+0.01)	1.05 (1.04, 1.07)	2.54×10−11	−0.02	0.91 (0.87, 0.96)	2.07×10−4	1.05 (1.04, 1.07)	1.78×10−11	−0.02	0.95 (0.90, 0.99)	4.18×10−2
Methyl tert-butyl ether (T12)	Air toxicant	log10(x+0.001)	0.80 (0.78, 0.83)	3.45×10−51	−0.09	0.90 (0.85, 0.94)	1.44×10−5	0.79 (0.77, 0.81)	6.56×10−59	−0.05	0.94 (0.89, 0.99)	1.34×10−2

^aT1: trimester 1; T2: trimester 2; T12: trimesters 1 and 2.

^bModels adjusted for age, race/ethnicity, education, marital status, WIC, smoking during pregnancy, pre-pregnancy BMI, parity, season of conception, and year of conception.

^cOdds Ratio (OR) and 95% Confidence Interval (CI) for each standard deviation increase.