FIG. 11.

Anti-hypothalamic antibody (AHA) immunoglobulin (Ig)M mediation model. This brain injury severity adjusted model demonstrates a mediation effect (by 31.91%) on the relationship between age and persistent hypogonadotropic hypogonadism (PHH) by AHA IgM levels. Increasing age was associated with lower levels of AHA IgM (month 1–6 means) and PHH. Greater month 1–6 mean AHA IgM levels were also associated with reduced odds of PHH. Each model leg adjusted for best in 24 h. Glasgow Coma Scale (GCS) score. Statistical significance denoted by: *p < 0.05, **p < 0.01. CI: confidence interval OR: odds ratio; SE: standard error.