Supplemental Table 3.

Investigator-assessed Best Overall Responses After Bortezomib-based Induction and After in-Class Transition to IRd by Age (n = 84)

Response	Age < 75 y (n = 47)		Age ≥ 75 y (n = 37)
	Bortezomib-based induction	iCT to IRd	Bortezomib-based induction	iCT to IRd
ORRa	27 (57) [42-72]	32 (68) [53-81]	25 (68) [50-82]	27 (73) [56-86]
≥VGPR	11 (23)	26 (55)	13 (35)	20 (54)
CRb	1 (2) [0.1-11]	14 (30) [17-45]	2 (5) [0.7-18]	8 (22) [10-38]
VGPR	10 (21) [11-36]	12 (26) [14-40]	11 (30) [16-47]	12 (32) [18-50]
PR	16 (34) [21-49]	6 (13) [5-26]	12 (32) [18-50]	7 (19) [8-35]

Data presented as n (%) [95% confidence interval].

Abbreviations: CR = complete response; iCT = in-class transition; IRd = ixazomib, lenalidomide, dexamethasone; ORR = overall response rate; PR = partial response; VGPR = very good partial response.

^aORR includes CR, VGPR, plus PR.

^bCR category includes patients who achieved CR, stringent CR, immunophenotypic CR, and molecular CR.