Figure 2. Black raspberries (BRBs) corrected dysregulated toll-like receptor (TLR)-4 signaling in colon and spleen of interleukin (IL)-10 knockout (KO) mice.

Heatmap of BRB-induced changes in genes in TLR pathways (A) and mRNA expressions of TLR-4, MYD-88, NF-κB, and COX-2 (B). WT, wild type (WT) mice fed control diet; KO, IL-10 KO mice fed control diet; BRBs, IL-10 KO mice fed 5% BRB diet. *P < 0.05, **P < 0.01, ***P < 0.001.