Figure 1:

Overview of pathological mechanisms that may be involved in cerebral small vessel disease (CSVD). Collagen dysfunction, distruption of vessel integrity, dissarangement of matrisome and increased permeabiliyt of blood brain barriers have been linked to genes and to macrosopic manifestations of CSVD, both in genetic epidemiology and studies on familial forms of the disease. The background color of genes and loci enlisted corresponds to at least one of the macroscopic manifestations of CSVD.