Table 1. Brief summary of RNA editing and modification factors in C. elegans.

C. elegans	Human Ortholog	Domains	Description
Adenosine to inosine RNA editing
adr-1	ADAD1	dsRBD, adenosine deaminase	ADR-1 physically interacts with ADR-2 and promotes editing of certain transcripts, ADR-1 can also inhibit editing by an unknown mechanism
adr-2	ADAR2	dsRBD, adenosine deaminase	ADR-2 is the sole adenosine deaminase acting on mRNA in C. elegans
adbp-1		None identified	ADBP-1 is important for nuclear localization of ADR-2 and RNA editing
Possible mRNA editing and mRNA modification enzymes in C. elegans
cdd-1	CDA	Cytidine deaminase	Loss of cdd-1 affects uridine metabolism, may also be involved in C-U editing of mRNA
cdd-2	CDA	Cytidine deaminase	Loss of cdd-2 affects uridine metabolism, may also be involved in C-U editing of mRNA
nsun-2	NSUN2	RNA C5-methyltransferase, SAM- dependent methyltransferase	Based on homology, NSUN-2 is predicted to have cytosine methyltransferase activity on tRNA and mRNA
B0024.11	PUS7	Pseudouridine synthase	Based on homology, B0024.11 is predicted to have pseudouridylation activity on RNA
—	METTL3	Adenine-N6-methyltransferase	No known homolog
—	METTL14	Adenine-N6-methyltransferase	No known homolog
mett-10	METTL16	Adenine-N6-methyltransferase	Based on homology, METT-10 is predicted to have N6-methyltransferase activity on rRNA

This table describes factors that are currently known to act in adenosine-to-inosine RNA editing in C. elegans. In addition, this table includes factors that are predicted to function in different types of RNA modification of mRNA.