Table 2 . C. elegans orthologs of human spliceosome component proteins.
| C. elegans | Human Ortholog | Domains | Description |
|---|---|---|---|
| snr-2 | SNRPB/Sm B/B’ | LSm | Sm protein (Common in U1, U2, U4 and U5 snRNPs) |
| snr-3 | SNRPDl/Sm D1 | LSm | Sm protein (Common in U1, U2, U4 and U5 snRNPs) |
| snr-4 | SNRPD2/Sm D2 | LSm | Sm protein (Common in U1, U2, U4 and U5 snRNPs) |
| snr-1 | SNRPD3/Sm D3 | LSm | Sm protein (Common in U1, U2, U4 and U5 snRNPs) |
| snr-6 | SNRPE/Sm E | LSm | Sm protein (Common in U1, U2, U4 and U5 snRNPs) |
| snr-5 | SNRPF/Sm F | LSm | Sm protein (Common in U1, U2, U4 and U5 snRNPs) |
| snr-7 | SNRPG/Sm G | LSm | Sm protein (Common in U1, U2, U4 and U5 snRNPs) |
| gut-2 | LSM2/Lsm2 | LSm | LSm protein (U6 snRNP) |
| lsm-3 | LSM3/Lsm3 | LSm | LSm protein (U6 snRNP) |
| lsm-4 | LSM4/Lsm4 | LSm | LSm protein (U6 snRNP) |
| lsm-5 | LSM5/Lsm5 | LSm | LSm protein (U6 snRNP) |
| lsm-6 | LSM6/Lsm6 | LSm | LSm protein (U6 snRNP) |
| lsm-7 | LSM7/Lsm7 | LSm | LSm protein (U6 snRNP) |
| lsm-8 | LSM8/Lsm8 | LSm | LSm protein (U6 snRNP) |
| rnp-7 | SNRNP70/U1-70K | U1 snRNP70, RRM | U1 snRNP |
| rnp-2 | SNRPA/U1A | RRM | U1 snRNP |
| snrp-3 | SNRPC/U1C | U1 Zn finger | U1 snRNP |
| prp-40 | PRPF40A/FBP11 | WW, FF | U1 snRNP |
| rbm-25 | RBM25/S164 | RRM, PWI | U1 snRNP |
| ddx-17 | DDX5/p68 | DEAD-box helicase | U1 snRNP |
| tcer-1, tcer-2 | TCERG1/CA150 | WW, FF | U1 snRNP |
| mog-2 | SNRPA1/U2A’ | Leucine-rich repeat | U2 snRNP |
| rnp-3 | SNRPB2/U2B” | RRM | U2 snRNP |
| prp-21 | SF3A1/SF3a120 | SWAP, PRP21-like, Ubiquitin | U2 snRNP |
| repo-1 | SF3A2/SF3a66 | C2H2 Zn finger | U2 snRNP |
| prp-9 | SF3A3/SF3a60 | SF3a60 binding | U2 snRNP |
| sftb-1 | SF3B1/SF3b155 | Sf3b1 | U2 snRNP |
| sftb-2 | SF3B2/SF3b150 | Proline-rich | U2 snRNP |
| teg-4 | SF3B3/SF3b130 | MMS1, CPSF A subunit region | U2 snRNP |
| sap-49 | SF3B4/SF3b49 | RRM | U2 snRNP |
| moa-2 | SF3B5/SF3b10 | SF3b10 | U2 snRNP |
| sftb-6 | SF3B6/SF3b14a | RRM | U2 snRNP |
| phf-5 | PHF5A/SF3b14b | PHD-finger | U2 snRNP |
| snu-13 | SNU13/hSnu13 | L7Ae | U4/U6 snRNP |
| prp-31 | PRPF31/hPrp31 | snoRNA binding, Prp31 | U4/U6 snRNP |
| prp-3 | PRPF3/hPrp3 | PWI, PRP3 | U4/U6 snRNP |
| prp-4 | PRPF4/hPrp4 | PRP4-like, WD40 repeat | U4/U6 snRNP |
| cyn-11 | PPIH/hCypH | Peptidyl-prolyl cis-trans isomerase | U4/U6 snRNP |
| prp-8 | PRPF8/hPrp8 | PROCN, RRM, U5-snRNA binding, U6-snRNA interacting, PRP8 domain IV, MPN, PROCT | U5 snRNP |
| snrp-200 | SNRNP200/hBrr2 | DEAD/DEAH box helicase | U5 snRNP |
| eftu-2 | EFTUD2/hSnu114 | GTP-binding, Elongation factor Tu, Elongation factor G | U5 snRNP |
| snrp-40.1, snrp-40.2 | SNRNP40/U5-40K | WD40 repeat | U5 snRNP |
| prp-6 | PRPF6/hPrp6 | PRP1, TPR | U5 snRNP |
| teg-1 | CD2BP2/hLin1 | GYF | U5 snRNP |
| dib-1 | TXNL4A/hDib1 | DIM1 | U5 snRNP |
| ddx-23 | DDX23/hPrp28 | DEAD-box helicase | U5 snRNP |
| snrp-27 | SNRNP27/U4/U6.U5-27K | U4/U6.U5 tri-snRNP | |
| usp-39 | USP39/hSad1 | Ubiquitin-hydrolases Zn finger, Ubiquitin carboxyl-terminal hydrolase | U4/U6.U5 tri-snRNP |
| sart-1 | SART1/hSnu66 | SART-1 | U4/U6.U5 tri-snRNP |
| rbm-42 | RBM42 | RRM | U4/U6.U5 tri-snRNP |
| uaf-1 | U2AF2/U2AF65 | RRM | U2 related |
| uaf-2 | U2AF1/U2AF35 | CCCH Zn finger, RRM | U2 related |
| rnp-6 | PUF60 | RRM | U2 related |
| smr-1 | SMNDC1/SPF30 | SMN | U2 related |
| dnj-30 | DNAJC8/SPF31 | DnaJ | U2 related |
| rbm-17 | RBM17/SPF45 | G-patch, RRM | U2 related |
| tag-65 | CHERP | SWAP, CTD-binding, G-patch | U2 related |
| sap-140 | U2SURP/SR140 | RRM, SWAP, cwf21 | U2 related |
| ddx-15 | DHX15/PRP43 | DEAH-box helicase | U2 related |
| ddx-46 | DDX46 | DEAD-box helicase | U2 related |
| hel-1 | DDX39B/UAP56 | DExD/H-box helicase | Transcription and export (TREX) complex |
| aly-1, aly-2, aly-3 | ALYREF/Aly/REF | RRM, Fop | Transcription and export (TREX) complex |
| thoc-1 | THOC1 | Thoc1, Death domain | Transcription and export (TREX) complex |
| thoc-2 | THOC2 | Thoc2 | Transcription and export (TREX) complex |
| thoc-3 | THOC3 | WD40 repeat, WD40- like beta propeller repeat | Transcription and export (TREX) complex |
| luc-7L | LUC7L | LUC7 | A complex protein |
| prp-39 | PRPF39 | PRP39 | A complex protein |
| tiar-1, tiar-2, tiar-3 | TIA1 | RRM, Q-rich | A complex protein |
| bub-3 | BUB3 | WD40 repeat | A complex protein |
| - | TRIR/MGC2803 | TRIR | A complex protein |
| - | SUGP1/SF4 | SWAP, G-patch | A complex protein |
| ccar-1 | CCAR1/FLJ10839 | S1-like RNA binding, DBC1, SAP | A complex protein |
| cdk-11.1, cdk-11.2 | CDK11A/CDC2L2 | Protein kinase | A complex protein |
| cus-2 | HTATSF1/Tat SF1 | RRM | A complex protein |
| fust-1 | FUS/TLS | RRM, RanBP Zn finger | A complex protein |
| rbm-5 | RBM5 | RRM, RanBP Zn finger, G-patch | A complex protein |
| rbm-5 | RBM10 | RRM, RanBP Zn finger, G-patch | A complex protein |
| sfa-1 | SF1 | KH, CCHC Zn finger | A complex protein |
| bud-13 | BUD13/MGC13125 | Bud13 | RES complex |
| pmlr-1 | SNIP1 | FHA | RES complex |
| rbmx-2 | RBMX2/CGI-79 | RRM | RES complex |
| snu-23 | ZMAT2/hSnu23 | dsRNA-binding Zn finger | B complex protein |
| prp-38 | PRPF38A/hPrp38 | PRP38 | B complex protein |
| mfap-1 | MFAP1 | MFAP1 | B complex protein |
| ubl-5 | UBL5 | Ubiquitin | B complex protein |
| smu-2 | IK/RED | RED-like | B complex protein |
| smu-1 | SMU1 | WD40 repeat | B complex protein |
| multiple genes | HSPB1/HSP27 | Hsp20 | B complex protein |
| dxbp-1 | KIN/HsKin17 | Kin17 curved DNA-binding | B complex protein |
| mtr-4 | MTREX/Skiv2L2 | DEAD/DEAH box helicase | B complex protein |
| prpf-4 | PRPF4B/hPrp4 kinase | Protein kinase | B complex protein |
| pqbp-1.1, pqbp-1.2 | PQBP1/NPW38 | WW | B complex protein |
| wbp-11 | WBP11/NPW38BP | WBP11 | B complex protein |
| wbp-4 | WBP4/FBP21 | U1 Zn finger, WW | B complex protein |
| mog-4 | DHX16/hPrp2 | DEAD/DEAH box helicase | Bact complex protein |
| let-858 | CWC22/KIAA1604 | MIF4G, MA3 | Bact complex protein |
| rnf-113 | RNF113A | CCCH Zn finger, RING finger | Bact complex protein |
| cyn-16 | CWC27/NY-CO-10 | Peptidyl-prolyl cis-trans isomerase | Bact complex protein |
| cyn-4 | PPIL2 | Rtf2 RING finger, Peptidyl-prolyl cis-trans isomerase | Bact complex protein |
| ccdc-12 | CCDC12 | cwf18 | Bact complex protein |
| cyn-10 | PPIL3/PPIL3b | Peptidyl-prolyl cis-trans isomerase | Bact complex protein |
| gkow-1 | GPKOW/hSPP2 | G-patch, KOW | Bact complex protein |
| prp-19 | PRPF19/Prp19 | U-box, PRP19-like, WD40 repeat | Prp19 complex (nineteen complex, NTC) |
| cdc-5L | CDC5L/CDC5 | Myb-like DNA-binding, Cdc5p/Cef1 | Prp19 complex (nineteen complex, NTC) |
| bcas-2 | BCAS2/SPF27 | BCAS2 | Prp19 complex (nineteen complex, NTC) |
| syf-1 | XAB2/hSyf1 | TPR | Prp19 complex (nineteen complex, NTC) |
| syf-2 | SYF2/GCIP p29 | SYF2 | Prp19 complex (nineteen complex, NTC) |
| syf-3 | CRNKL1/hSyf3 | HAT repeat | Prp19 complex (nineteen complex, NTC) |
| isy-1 | ISY1/hIsy1 | Isy1-like | Prp19 complex (nineteen complex, NTC) |
| ctnb-1 | CTNNBL1/catenin beta like 1 | Catenin-beta-like | Prp19 complex (nineteen complex, NTC) |
| hsp-1, hsp-70, F44E5.4, F44E5.5, F11F1.1 | HSPA8/Hsp73 | Hsp70 | Prp19 complex (nineteen complex, NTC) |
| rbm-22 | RBM22 | RRM | NTC-related (NTR) complex |
| skp-1 | SNW1/SKIP | SKIP/SNW | NTC-related (NTR) complex |
| bud-31 | BUD31/G10 | G10 | NTC-related (NTR) complex |
| cyn-12 | PPIL1 | Peptidyl-prolyl cis-trans isomerase | NTC-related (NTR) complex |
| cwc-15 | CWC15/AD-002 | Cwf15/Cwc15 | NTC-related (NTR) complex |
| plrg-1 | PLRG1/PRL1 | WD40 repeat | NTC-related (NTR) complex |
| emb-4 | AQR/Aquarius | AAA | NTC-related (NTR) complex |
| sel-13 | ZNF830/CCDC16 | C2H2 Zn finger | Intron-binding complex (IBC) |
| cyn-13 | PPIE/CypE | RRM, Peptidyl-prolyl cis-trans isomerase | Intron-binding complex (IBC) |
| cwf-19L2 | CWF19L2 | CwfJ | Intron-binding complex (IBC) |
| F33D11.10, Y65B4A.6 | EIF4A3/eIF4A3 | DEAD/DEAH box helicase | Exon junction complex (EJC) |
| mag-1 | MAGOH | Mago nashi | Exon junction complex (EJC) |
| rnp-4 | RBM8A/Y14 | RRM | Exon junction complex (EJC) |
| casc-3 | CASC3/MLN51 | Btz | Exon junction complex (EJC) |
| mog-1 | DHX38/hPrp16 | DEAH-box helicase | Step 1 factor |
| yju-2 | YJU2/CCDC94 | YJU2 | Step 1 factor |
| mog-3 | CWC25/CCDC49 | CIR, CWC25 | Step 1 factor |
| sacy-1 | DDX41/Abstrakt | DEAD-box helicase | C complex protein |
| cacn-1 | CACTIN | Cactin | C complex protein |
| ddx-35 | DHX35/DDX35 | DEAH-box helicase | C complex protein |
| gpch-1 | GPATCH1/Q9BRR8 | G-patch | C complex protein |
| cyn-15 | PPWD1 | WD40 repeat, Peptidyl-prolyl cis-trans isomerase | C complex protein |
| Y66D12A.8 | CXorf56 | UPF0428 | C complex protein |
| T23G11.4 | C9orf78 | HCA59 | C complex protein |
| cyn-8 | PPIG | Peptidyl-prolyl cis-trans isomerase | C complex protein |
| C08H9.16 | FRA10AC1 | Fra10Ac1 | C complex protein |
| frg-1 | FRG1 | FRG1-like | C complex protein |
| wdr-83 | WDR83/MORG1 | WD40 repeat | C complex protein |
| ess-2 | ESS2/DGCR14 | Es2 | C complex protein |
| R05G6.4 | NOSIP | NOSIP | C complex protein |
| sde-2 | SDE2/C1orf55 | Sde2 | C complex protein |
| C47E8.4 | FAM50A, FAM50B | XAP5 | C complex protein |
| K01G5.8 | FAM32A | FA32A | C complex protein |
| rsr-2 | SRRM2/SRm300 | cwf21, SRRM | C complex protein |
| prp-17 | CDC40/hPrp17 | WD40 repeat | Step 2 factor |
| prp-18 | PRPF18/hPrp18 | PRP18 | Step 2 factor |
| mog-5 | DHX8/hPrp22 | DEAH-box helicase | Step 2 factor |
| sluh-7 | SLU7 | Pre-mRNA splicing Prp18-interacting factor | Step 2 factor |
| F37A4.2 | PRKRIP1 | PRKRIP1 | Step 2 factor |
This table describes C. elegans orthologs or closest homologs of human spliceosomal protein components described in Wahl and Luhrmann (2015) with some updates.