Figure 9.

Model of how Ydj1 regulates activity of Ssa2 and Ssa4. Misfolded v-Src interacts with Ydj1. Ydj1 further recruits v-Src to Hsp70. Solid black arrow represents transfer of v-Src to Ssa2 while dashed arrow represents the fact that Ydj1 is not able to transfer v-Src to Ssa4. Lack of Ydj1-Ssa4 interaction results in degradation of v-Src and cell survival in Ssa4 background. Hsp90 interacts with Ssa2, thus v-Src is transferred to Hsp90 and gets matured. v-Src maturation through Hsp90 results in cell death in Ssa2 background.