Table 1.

Interactions of Inhibitors with Eis Residues of Interest

Eis residue/ligand	TOB	inhibitor 1	inhibitor 2	inhibitor 3
F24	hydrophobic	π–π
D26	salt bridge	H-bond	steric	salt bridge
W36	H-bond/steric	π–π stacking	π–π stacking	π–π stacking
R37		hydrophobic	hydrophobic	hydrophobic
L63		hydrophobic	hydrophobic	hydrophobic
M65		hydrophobic	hydrophobic	hydrophobic
S83	H-bond	steric	steric	steric
F84	hydrophobic	π–π stacking	π–π stacking	π–π stacking