Table 2.

Influence of APOE genotype on the efficacy of acetylcholine-esterase inhibitors traditionally used in Alzheimer’s disease

Medication	Reference
Interpretation: influence of APOE genotype on therapeutic response
Donepezil
Patients with Alzheimer’s disease carrying the APOE ε-4 allele may respond better to donepezil than noncarriers	106
Tacrine
Faster rate of cognitive decline in APOE ε-4 allele carriers treated with tacrine	107
Galantamine
APOE genotype does not influence the efficacy of galantamine therapy in Alzheimer’s disease	108
APOE genotype does not influence cognitive improvement related to galantamine treatment in Alzheimer’s disease	109
Rivastigmine
Moderately severe Alzheimer’s disease patients with the APOE ε4 allele may respond more favorably to memantine plus rivastigmine patch than noncarriers	110

Abbreviation: APOE, apolipoprotein E.