Table 1.

Baseline characteristics of the 6 study groups

	Testosterone Dose and Group
	Group 1	Group 2	Group 3	Group 4	Group 5	Group 6
	0 g/day	1.25 g/day	2.5 g/day	5 g/day	10 g/dayc	PBO/PBO
N	26	25	31	35	29	31
Age (y)	66 ± 5	64 ± 3	64 ± 4	65 ± 4	65 ± 3	65 ± 4
BMI (kg/m2)	28.0 ± 3.9	27.3 ± 4.3	26.3 ± 4.3	27.1 ± 4.2	28.2 ± 3.5	26.9 ± 4.2
Testosterone (ng/dL)a	496 ± 176	485 ± 117	491 ± 142	483 ± 165	484 ± 148	505 ± 155
Estradiol (pg/mL)b	27 ± 7	26 ± 11	25 ± 8	30 ± 11	26 ± 6	28 ± 7
C-telopeptide (mg/mL)	0.34 ± 0.17	0.37 ± 0.17	0.41 ± 0.18	0.37 ± 0.20	0.42 ± 0.21	0.42 ± 0.21
Lumbar spine BMD (g/cm2)	1.13 ± 0.15	1.12 ± 0.20	1.08 ± 0.17	1.15 ± 0.19	1.08 ± 0.15	1.11 ± 0.19
Femoral neck BMD (g/cm2)	0.81 ± 0.08	0.86 ± 0.13	0.80 ± 0.11	0.84 ± 0.15	0.83 ± 0.11	0.82 ± 0.15
L4 trabecular BMD (g/cm3)	106 ± 39	115 ± 38	98 ± 25	108 ± 24	107 ± 30	105 ± 28
Total body fat mass (g)	22 773 ± 8693	20 827 ± 7208	19 396 ± 7267	23 062 ± 11124	22 803 ± 7459	19 932 ± 7574
Total body lean mass (g)	56 177 ± 6417	55 553 ± 8218	58 428 ± 8054	55 653 ± 9206	56 081 ± 6116	52 867 ± 6637
Subcutaneous fat area (mm2)	20 693 ± 9678	19 655 ± 10764	18 659 ± 8596	22 018 ± 11416	23 012 ± 10295	20 023 ± 9736
Intraabdominal fat area (mm2)	15 681 ± 9615	12 973 ± 8063	12 850 ± 7583	14 536 ± 7038	18 813 ± 9210	15 214 ± 9672
Thigh muscle area (mm2)	15 272 ± 2026	16 006 ± 2575	15 281 ± 2045	15 367 ± 2820	15 771 ± 2145	15 772 ± 2157
Thigh fat area (mm2)	7026 ± 2819	6036 ± 6583	5763 ± 2413	6311 ± 3255	6556 ± 2172	6025 ± 2461

Values are expressed as the mean ± SD.

^aTo convert testosterone to nmol/L, multiply by 0.03467.

^bTo convert estradiol to pmol/L, multiply by 3.671.

^cIndicates that men in Group 5 received either 7.5 or 10 g/day of testosterone gel.